In the present work newly hatched larvae of Pink bollworm, Pectinophora gossypiella (Saund.) were fed on diet treated with LC₅₀ of four compounds two IGR's, chromafonozide 80% & diflubenzeroun48% and two oils super misrona (mineral oil) & linseed oil( botanical oil) to investigate their toxicity, biological aspects and the biochemical impactsin full grown larvae.                 Obtained results show that the tested compounds affected the PBW larvae by increasing larval and pupal duration, total immature stages, pre oviposition, oviposition and post oviposition period, on contrary these compounds decrease weight of larvae and pupae, longevity of females and males, fecundity of females (total laying eggs/♀) and the percentages of egg hatchability than untreated ones. In addition ,the biochemical analysis revealed that the tested compounds, Chromafonozide, Diflubenzeroun, mineral oil and linseed oil when used at LC₅₀ values caused significant reduction in soluble protein ,total lipids and ALT and AST content in adult  which caused inhibition and/or reduced the reproductive potentiality compared to control.