This study was conducted to investigate the concentrations of heavy metals and pesticides in waste water from three main drains in Egypt . The drains were Belbais drains , Baher EL – Baker drain and EL – Kalubia drain . Samples were taken from the end of each drain monthly for 12 months from the period of April 2015 to March  2016 to determine heavy metals and for the pesticides residues at February 2016 and Co , Cr , Fe , Mn , B , Pb , Cd , Ni , Zn using flame atomic absorption spectrometry . Results show that the concentrations of some heavy metals exceeded their respective permissible limits in water samples .The average of concentrations for (zinc , manganese and cadmium ) were  0.72  , 0.44, 0.02 mg/ L in  EL – Kalubia drain and  0.7 ,0.38 , 0.02 mg/ L in Belbais drain, respectively , while in Baher EL – Baker drain were 0.54 and 0.05mg / L  for zinc and cadmium ,respectively . These concentrations were  exceeded compared with the recommended maximum concentrations for irrigation . The corresponding figures were different in pesticides residues . Results show that the concentrations of Endosulfan 11 were 0.06 ug / g in  Belbais drain ,Endrin were 2.12 ug / gm in  EL – Kalubia drain and the Trichlorfen pesticide were 0.01 , 0.19 ug/g in EL – Kalubia and Baher EL – Baker drains, respectively.