The present study is directed to evaluate the effect of five compounds of different mode of action, four pesticides (Abamectin benzoate; Cypermethrin, Profenofos and Chlorpyrifos) and one natural oil(Neem oil) against the eggs and adult females of the two spotted spider mite Tetranychus urticae (Koch) on three different host plants (maize, cotton and soybean) using leaf-disc dip technique.Also,to evaluate these compounds on toxic effect of spider mite T. urticae on different host plants under filed conditions. Abamectin benzoate has a special position in mite chemical control or in integrated mite management because of  its high toxic effect and its high toxicity index  whileneem oil was the least toxic compound to adult femalesof  T. urticae on different host plants. Abamectin benzoate has a special effect on eggs of T. urticae and still considered the best compound that has a special importance in  integrated mite management.Cypermethrin was the most effective compound against the motile stages, whileneem oil was the least effective compound against the motile stages of T.urticae in the field.