Two field experiments were carried out in Alexandria and El-Beheira governorates in Egypt to evaluate the biological efficacy of a ready mix herbicide Paradigm (Halauxifen-methyl + Florasulam) with application rate 21 gm/fed combined with Pyroxsulam (160 ml/fed), Pinoxaden (550 ml/fed), Clodinafop-propargyl (140 gm/fed) and Diclofop-methyl (1000 ml/fed) compared to Pyroxsulam (Pallas), Atlantis (Iodosulfuran + Mesosulfuron) and unweededcheck on winter wheat in 2014, herbicides were applied at tillering stage in both regions. Paradigm with its combinations with grassy weed herbicides showed excellent control onMedicagohispida, Beta vulgaris, Malvaprviflora, Anagallisarvensis, Coronopussquamatus, Sonchusoleraceusand Brassica nigra .On the other hand, the best efficacy on grassy weed mass, visual weed estimation  and percentage of grassy seed heads were obtained from Paradigm combinations with Pyroxsulam and Pinoxaden only at tillering stage in Alexandria region, while its combination with Clodinafop-propargyl and Diclofop-methyl did not improve grassy herbicidal activity in both trials compared to standard herbicides, Generally the combinations showed good control for broad weed leaves in both locations, while in grassy leaves it showed better control in Alexandria than in El-Beheira governorate.