Alternative non-conventional and environmentally safe means of control of Cryptoblabes gnidiella (Lepidoptera: Pyralidae) in pomegranate orchards by horticultural, mechanical, microbial, and local chemical treatments were evaluated at El-Alamain district, Matrouh Governorate in the northwestern of Egypt during one and two successive years (2015 and 2016). The respective reductions rates of infestation with the following 12 treatments applied for one and two successive years were as follows: dormant pruning (4.04% increased to 4.17%), summer pruning (1.01 increased to 1.39%), dormant and summer pruning (6.06 increased to 8.89%), worming (36.36 increased to 44.44%), bacterial or fungal (14.14 or 10.10 increased to 18.06 or 11.11% ,respectively), local painting or local spraying (72.73 or 78.79 increased to 83.33 or 88.89%, respectively), pruning, worming, together with bacterial or fungal (52.53 or 48.49 increased to 58.33 or 56.94%, respectively), while pruning, worming, and local painting or local spraying treatments (82.83 or 90.91 increased to 91.67 or 95.83% ,respectively). Accordingly, it could be recommended that control of C. gnidiella could be effectively achieved by the safe means such as worming and local painting or spraying on the infestation sites in the crown of the stem.