Field studies were conducted during 2015 and 2016 cotton growing seasons, at AbouElmatameer, El-Behira Governorate to evaluate certain insecticide sequences in controlling two cotton bollworms pink bollworm (PBW), Pectinophora gossypiella, (Saund) and spiny bollworm (SPW), Earias insulana, (Boisd.) The side effects of all insecticide sequences on the lady beetle, Coccinella undecimpunctata was also determined. During 2015 season, sequence 2 (Dursban^®, Rado-X^®, Radiant^®, Cothrin^®) and sequence 6 (Dursban^®, Rado-X^®, Radiant^®, Proclaim^®) achieved the highest efficacy against PBW, gave general mean reduction percentages 81.4 and 83.5%, respectively. In season 2016, sequence 6 revealed the highest efficacy where the general mean reduction percentage was 83.3%. Sequences 6 induced the highest reduction percentages in cotton bolls infested by SBW in 2015 and 2016 seasons, with general mean reduction percentages 84.0 and 82.3%, respectively. Sequence 4 (Cothrin^®, Radiant^®, Rado-X^®, Dursban^®) achieved the least efficacy against PBW and SBW in both seasons 2015 and 2016. Sequence 6 proved to be the least toxic on C. undecimpunctata. On the other hand, all other sequences were comparable in there effects on C. undecimpunctata in both seasons.