The efficiency of three isolates of entomopathogenic nematodes indigenous in Egypt, (i. e. Heterorhabditis bacteriophora (EKB20), Steinernema sp. (B32)and Heterorhabiditis sp. (Kasassien isolate)) were determined in the laboratory and field compared with imidacloprid insecticide on the larvae and adults of the red Palm weevil, Rhynchophorus ferrugineus.Results showed that isolates of entomopathogenic nematodes, B32 and EKB20 are more effective than Kasassien against R. ferrugineus larvae at inoculum levels of 1000 and 2000 Infective Juveniles (IJs)/mL. Both isolates of B32 and EKB20 were faster killers achieving more than 90% mortality to the 3^rd instar larvae of the red palm weevil after 72 hrs.  Field evaluation showed that Kasassien and EKB20 achieved higher levels of control against diferent stages of R.  ferrugineus reaching100% reduction than the isolate B32 (80.33 % reduction). When the level of palm weevil infestation was moderate (1-3 weevil tunnels/ tree, the reduction percent was 80.33, 100 and 80.66% when the trees were treated with EPN isolates of EKB20, Kasassien and B32 respectively. There was no significant effect when the trees with higher infestation (more than 3 tunnels/palm tree) level were treated with EPN. While as imidacloprid insecticide gave 100% mortality in the three levels of infestation. The current work has indicated that EPN are considered promising biocontrol agents, if correctly applied and released in an integrated control schemes against the red palm weevil.