The cotton mealybug, Phenacoccus solenopsis Tinsley is an invasive polyphagous pest species causing severe economic damage to a wide range agricultural crops. Five different toxicants of different groups were evaluated for their effectiveness in reducing mealybug incidence on cotton under both laboratory and field conditions as well as their effectiveness against its associated predators (Chrysoperla carnea (Steph.), Hyperaspis vinciguerrae Capra) under field conditions. Chlorpyrifos and Imidacloprid were the most toxic insecticides after 24h and 72h of exposure compared with Pyriproxyfen, Buprofezin and Emamectin benzoate against third instar nymphs of P. solenopsis under laboratory conditions. Based on field experiments, Chlorpyrifos significantly superior in reducing the cotton mealybug population followed by Imidacloprid, Pyriproxyfen, Emamectin benzoate and finally Buprofezin with average reduction between 96.24 to 43.99%. IGRs toxicants (Buprofezin and Pyriproxyfen) found to safer to the predacious insects than other toxicant groups.