Under high plastic tunnels in a private farm at Behbate El-hegara village, Samannoud District, El-Gharbia Governorate, Egypt, two field experiments were conducted during 2017/2018 and 2018/2019 seasons, respectively. These experiments were conducted to study the effects of grafting, some foliar applications (ascorbic acid, chitosan and salicylic acid) and their interactions on vegetative growth, leaf pigments, fruits yield and quality of two cucumber cultivars (King-53 and Sultan). Comparing the cultivars, Sultan cultivar was superior to King-53 cultivar in all studied parameters in both growing seasons. Grafted plants perform better than non-grafted ones. The obtained results indicated that the maximum values of all studies characteristics were recorded by grafted plants. Concerning the applied foliar substances, plants sprayed with salicylic acid at 200 ppm recorded the best values of all studied vegetative growth, leaf pigments, fruits yield and quality followed by spraying chitosan at 250 ppm. From the obtained results, it can be concluded that grafting Sultan cucumber cultivar and spraying salicylic acid at 200 ppm is the best combination to obtain the highest vegetative growth, leaf pigments, fruits yield as well as quality under high plastic tunnels and the environmental conditions of the experiment.