Two field experiments were conducted during the summer seasons of 1995 and 1996 in the Agricultural Experimental Station, at Abies, Alexandria University, to study the effects of four N levels (0,30, 60 and 90 kg N fed.^-1) and four K levels (0, 36, 72 and 108 kg K₂o fed.^-1) on vegetative growth, flowering, yield and mineral contents of pumpkin plants. The results, generally, indicated that increasing N applied rate up to Kg N fed.^-1 promoted vegetative growth characters; i.e main stem length plant^-1 average branch length, no. of leaves plant^-1, average internode length and shoot fresh weight plant^-1. Moreover, flowering traits; i.e no. of male and female flowers were increased as a result of increasing N up to 60 kg N fed.^-1. However, number of nodes below the first five male and /or female flower decreased. The highest fruit set percentage was obtained from the highest N rate (90 kg N fed.^-1). In addition, application of 60 kg N fed^-1. was adequate to produce more number of marketable fruits fed.^-1, larger fruit size and higher total yield fed.^-1 leaf's N and K contents, positively and significantly, reflected the amount of N applied level, however, leaf's P content was not affected. The results showed that the intermediate K level of 72 kg K₂O fed.^-1, greatly improved some vegetative growth characters as well as fruit yield potential, number of marketable fruits fed.^-1, average fruit weight and total yield fed.^-1. Increasing K level led to a significant increase in leaf's K and N contents. The interaction effect of N by K was significant on some of the studied traits.  Application of 60 kg N fed.^-1 in combination with 72 kg K₂o fed.^-1 seemed to be the most efficient and economical combination treatment which assure a better vegetative growth and a higher fruit yield of pumpkin plants.