In two field trials conducted during the 1996/97 and 1997/98 seasons, eleven new bread wheat genotypes were subjected to a lower N application (168 kg/ha) and to a higher dose (240 kg N/ha) under two irrigation levels (3000 and 5000m3/ha) to study their performance and water-use efficiency in the newly reclaimed land at El-Bustan region. The results revealed that both irrigation and nitrogen fertilizer treatments had significant positive effects on wheat grain yield and its contributing characters. Significant differences among the studied genotypes for grain yield were obtained. Entries No 6, 8, 7, 5, 4and 3 were statistically at par and outyielded the other genotypes irrespective of the other treatments. Substantial difference among the genotypes in their response to increasing N fertilizer rate was observed. Grain yield response index (GYRI) of the different genotypes was improved with increasing the irrigation level. Significant genotypic variation for water-use efficiency (WUE) was obtained and it was higher for the high-yielding genotypes. (WUE) of the different genotypes decreased with increasing irrigation water supply, and vice versa with increasing nitrogen application. Moreover, entry No 7 produced high grain yield with lower and / or higher levels of both irrigation and fertilization. Therefore, this line is highly recommended for the wheat national research program to be evaluated for further advanced steps.