Increasing crop production by using intercropping is considered as one of the recent means which used for this goal. Maize-soybean intercropping was studied under different patterns to distinguish the best pattern for decreasing kernel and ear rot diseases of maize and pod, seed rot as well as leaf spot of soybean, with the optimal production of both crops. Three intercropping patterns were used. It was found that 2 x 2 pattern (two ridges of maize in alternation with two ridges of soybean) increased disease incidence for both crops, specially F. moniliforme var. zea, accompanied with decreasing the production characteristics of both crops. On the other hand, intercropping pattern 2 x 4 (two ridges of maize in alternation with four ridges of soybean) decreased diseases incidence and accordingly improved production characteristics for both crops. Generally, sole pattern of soybean produced the best crop productivity, but sole maize pattern produced moderate crop characteristics and disease incidence compared with 2 x 4 pattern which gave the lowest infection of Fusarium and highest crop production characteristics.