Wheat grains Triticum aestivum L. var. Sakha 69 were sown under different irrigation intervals and other plants were sprayed with chemical desiccants 10 days after anthesis. The plant canopy was hand sprayed with KI (0.15 % and 0.3 %) and  NaClO₃ (1 % and 2 %).                 The visual effect of chemical desiccants was observed after one week of treatment Reduction percentage for both growth and yield, showed that  0.3 % KI and 2 % NaC10₃ reduced significantly growth  and yield parameters with less extent than drought caused by elongation of irrigation interval. High moisture stress favoured accumulation of protein content  in grains and straw and accumulation of free amino acids as well as proline in shoots of wheat plant. Also total sugars and total soluble phenols were increased in plant shoots under intense drought. Additional index words :                 Senescence agent - yield components - chemical desiccants – drought - potassium iodide - sodium chlorate protein - proline - phenols - total sugar and free amino acids.