Two field experiments were carried out during the two growing seasons of 2019/2020 and 2020/2021 at the El Kanater Hort. Res. Station, El Kaloubia governorate Egypt, to study the effect of irrigation with normal water, magnetized water at 100, 75% of potential evapotranspiration, under different levels of N, P and K of the recommended doses fertilization and their combined interactions on productivity and water use efficiency of globe artichoke. The experiment design was a split plot with three replicates and the main plots were allocated to irrigation water treatments whereas the sub-plots were concerned with NPK fertilizer levels. The results indicate that irrigation with 75 or 100% ETc magnetic water produced the maximum vegetative growth, early and total yield / plant and ton/fed, head dry matter percent, inulin content, water use efficiency and head NPK percentages. The optimal NPK fertilizer rate for artichoke plants is 75% and irrigation with magnetized water at 75% ETc mixed with NPK fertilizers at 75% of recommended rates produced the best interaction of yield characters and its constituent. The highest water use efficiency (7.51 kg m-³and 7.40 kg m-³)) was obtained by 75% ETc magnetized mixed by100 or 75 % NPK as well as ETc 75% magnetized water combined with 75% of recommended NPK (9.21 kg m-³) in the first and second season respectively, It might be concluded that irrigated artichoke plants with 75% ETc magnetized water and fertilize with 75% of recommended NPK resulted in a 25% reduction in irrigation water and NPK fertilization.