The experimental were conducted during the two successful summer seasons of 2019/2020 and 2020/2021, in a private farm, at Abu Al- Matamir city, Al-Behiera Governorate, Egypt, under open field condition, with surface irrigation system aiming to evaluate the response of potato tubers “Cara cultivar" to soaking before planting in "NAA" as auxin and synthetic cytokinin “CPPU" and the effects on vegetative growth, yield and its components and quality as well as the production of safe and economic potato tubers. The treatments comprising two times of soaking i.e., 5 and 10 min  as main plot, three concentration treatments of (CPPU) as synthetic cytokinin i.e., 0.0, 5.0, 10.0 mg L^-1) as sub plot and three levels of NAA as auxin (0, 5 and 10 mg L^-1).The results indicated that soaking cut tuber explants before planting for 10 min in growth regulators solution was more superior for increasing vegetative growth parameters such as plant height, number of leaves and branches , yield (average tuber weight, number of tuber and total yield ton.fed^-1), tuber quality (starch, TSS and total sugars %) and nutrition values in leaves and tubers (N, P and K%). Moreover, soaking in 10 mg L^-1 CPPU mixed with 10 mg L^-1 NAA for each of 5 or 10 min. increased all mentioned parameters. Generally, it could be concluded that soaking cut tuber explants of potato in 10 mg L^-1 CPPU mixed with 10 mg L^-1 NAA for 10 min before planting gave highest gross and economic yield of potato plants.