The present investigation was conducted to study the effect of different doses of gamma-rays on four varieties and all hybrids among them of snake cucumber. In this respect, variation, the magnitudes of genetic parameters correlation coefficient between traits were also studied. Seeds of all genotypes were exposed to three doses of gamma-radiation emitted from cobalt 60 source. The doses used were :  zero (control), 6 , 12 and 18 kr. The sensitivity of genetic material were measured for the studied traits : (P.L cms), (No.L/p) , (E.Y/P gms) , (A.F.W gms) , (Th.F cm) , (F. L cm) , (F.D cm) and (T.Y/P kgs) . The results showed that the dose of 6 kr. treatment  exhibited  the highest value of means for most studied traits. The obtained values of heterosis, genetic parameters and heritability also showed that 6 kr. treatment was the best. Coefficient of correlation showed that genotypic and phenotypic correlations were positive for all studied traits. Consequently selection for increasing one trait would increase the other related traits.