During 2020 and 2021 growing seasons, a randomized complete block design with three replications was used to examine sixteen F₁ hybrids produced from Line x Tester and their eight parents under saline sodic conditions. This study's main objective was to examine the links between eight different rice genotypes and their offspring from the first generation (F₁) by examining heterosis and combing ability. The best combinations were Giza 178 x GZ1368, Giza 178 x GZ9399, GZ10365 X G179, and Sakha 104 x GZ1368 regarding to grain yield^-1, number of panicles plant^-1, panicle weight, and sterility percentages. These paternal lineages might be used in further breeding initiatives. Positively, there is a strong positive heterosis for the number of panicles per plant, grain yield plant ^-1, and the number of field grains per panicle and 1000-grain weight. The crosses Giza 177 x GZ9399, Giza 178 x GZ13684, and Giza 178 x GZ9399 were among the finest. These lines can be used in breeding programs under saline soil conditions.