This study was carried out at Ras Sudr Experimental Station, South Sinai during 2003/2004 and 2004/2005 growing seasons. Two bread wheat cultivars (Giza 168 and Seds1) were tested with four mineral and biological nitrogen fertilizer and three mineral and biological phosphorous fertilizer treatments under salinity water irrigation conditions. Growth, yield and yield attributes and some chemical components were measured Results showed that Giza 168 cultivar surpassed Significantly Sedsl cultivar in most yield and yieid attributes Increasing mineral nitrogen and phosphorus fertilizers dose increased significantly all growth traits (i e plant height and number of tillers/plant), yield and yield attributes (ie. spike length, number of spikelets/spike. number of grains/spike, spike weight, grains weight/plant, 1000 grains weight, number of spikes/m", grain yield/fed , straw yield/fed . biological yield/fed.) and some chemical components (ie. %protein and %total carbohydrate) of the two wheat cultivars Giza 168 cultivar fertilized with 100 kg/N/fed., and 31 kg/P/fed., produced the highest significant values of spike length, number of spikelets/spike, number of grains/spike and 1000-grains weight. Meantime, Sedsl cultivar fertilized with 100 kg/N/fed, and 31 kg/P/fed had high significant values of grains weight/plant. grain yield/fed. and straw yield/fed. traits Usmg N biofertilizer {Ceraline) produced about 78% of wheat grain yield compared With using 100 kg IN! fed On the other hand using P biofertilizer produced about 84% of wheat grain yield compared with using 31 kg /P/ fed