Four methods of breeding or selection representing different cycles phenotypic selection were evaluated in six spring bread wheat (Triticum aestivum L.) crosses. The methods were : 1-    The pedigree method (PM) with three cycles of breeding selection in F₃, F₄ and F₅. 2-    The modified bulk₁ (MB₁) two the cycles of breeding or selection in F₄ and F₅ were practiced. 3-    The modified bulk₂ (MB₂) where only one cycle of breeding or selection in F₃ was exercised. 4-   The bulk method where only natural breeding or selection were involved (BM). This study was conducted at the farm of El-Giza Agric. Res. Stn., ARC, Egypt, during four successive seasons from 2001/2002 to 2004/2005 to evaluate the efficiency of four different breeding or selection methods in improving grain yield potentiality and some other agronomic traits in six bread wheat crosses. The lines which were produced from various cycles were evaluated in terms of number of spikes/plant, number of kernels/spike, 100 kernel weight, kernel spike weight and grain yield/plant.                 Results of single analysis of variance for every cross showed significant differences for selection methods in all crosses. Genotypes showed significant variation in number of spikes/plant except for crosses No. 4 and 5, in number of kernels/spike and 100 kernel weight except for crosses No. 1 and 5, in kernel spike weight and grain yield/plant except for cross No. 1. The interaction between genotypes and methods of selection was significant in all studied characters for all crosses except for number of spikes/plant in crosses No. 4 and 6, number of kernels/spike except for cross No. 6 , 100 kernel weight except for cross No. 1, kernel spike weight and grain yield/plant.                 Analysis of variance for methods of selection, crosses and genotypes showed significant differences for crosses (C), methods of selection (M), genotypes (G), and the interactions of (C x M), (C x G), (M x G) and (C x M x G).                 The best methods of selection for number of spikes/plant was (BM) followed by (PM), for number of kernels /spike (MB₂), followed by (PM), for 100 kernel weight (MB₁) followed by (MB₂), for kernel spike weight (MB₂), followed by (PM) and for grain yield /plant, (MB) followed by (MB₂).                 Results revealed that six bread wheat crosses differed in all studied characters. Cross No. 6 had the highest number of spikes/plant, cross No. 3 had the highest number of kernels/spike, 100 kernel weight and kernel spike weight, cross No. 5 had the highest grain yield/plant.