Two field experiments were carried out at Kaha, Qalubia Governorate, Egypt, during winter seasons to investigate the response of potato plants (Synergy variety) to compost rice straw (CRS) application with seven foliar spray treatments (Sorbitol, Seaweed extracts and Amino acid). Results indicate that 5 m³/fed (CRS) gave a superior impact in all vegetative growth characters, chemical constituents and caused an increase in yield and its components compared with the control treatment for both seasons. The highest values of total yield per feddan, marketable yield, yield per plant and average tuber were obtained by spraying plants with the highest level of amino acids (AA-1000) followed by Sorbitol (SrB-50 g/L) compared with other treatments in both seasons. However, application of CRS to soil and spray with a high concentration of amino acid or Sorbitol lead to a significant increment in total yield per feddan, marketable yield, total yield per plant, number of tubers/plant and average tuber weight, as well as large size tubers comparing with other interactions in both season.