Twenty isolates of Macrophomina phaseolina from cotton roots were evaluated in vivo for sensitivity to the seed-dressing fungicides Monceren, Monceren T, Rizolex T, Vitavax 200, and Maxim AP. Monceren and Rizolex T were the best performing fungicides in suppressing M. phaseolina under greenhouse conditions. This superiority was attributed to the following reasons: first, they were effective in increasing the percentage of surviving seedlings by 203.09 and 170.10%, respectively, regardless of the tested isolate. Second, they were also effective in increasing the height of surviving seedlings by 93.21 and 62.57%, respectively. Third, Monceren and Rizolex T were effective in increasing the dry weight of surviving seedlings in 50 and 40% of the tested isolates, respectively. A high significant positive correlation was observed between pathogenicity of isolates and their sensitivity to fungicides.