A greenhouse experiment was conducted to study the reaction of three potato cultivars i.e. Cara, Draga, Spunta to Meloidogyne incognita infection through certain plant growth parameters; and rate of nematode reproduction and development. Results indicated that all tested parameters were obviously reduced by M. incognita infection to various degrees. Of the potato cultivars tested, sponta showed the highest percentage of reduction values of plant length (60.3%), total fresh weight of plant (35.7%), shoot dry weight (16.7%), tuber diameter (35.7%), number of tuber (40%), tuber fresh weight (49.2%), number of leaves/plant (27.3), and Leave area (16.2%)., respectively, followed by Draga and Cara cultivars in certain growth Parameters as compared with the uninoculated ones. Due to the relationship between root gall index (RGI) and reproduction factor (RF), Draga and Cara cultivars were rated as resistant hosts, whereas, Sponta cultivar was considered as susceptible host to Meloidogyne incognita, since its root gall index was 3 (RGI≥2), associated with R factor value of 1.89(R≥1). With respect to the status of nitrogen, phosphorus, and potassium concentrations in leave or tuber as well as starch content, T.ss %, vitamin-C in tuber and total chlorophyll in leave for the potato cultivars tested against M. incognita, infection were recorded and discussed.