Two field trials were conducted in the Experimental Farm of Itai AL-Baroud Agricultural Research Station, Al-Behiara Governorate, Egypt, during 2018/2019 and 2019/2020 seasons. The purpose of these experiments was to investigate the effects of three irrigation regimes (excluding sowing irrigation) and three tillage depths (zero tillage (ZT), conventional tillage (CT), and deep tillage (DT)) on physical properties of soil, yield and its components, and water use efficiency (WUE) of wheat cultivar Misr-3. Results indicated that hydraulic conductivity was significantly affected by tillage depths and number of irrigations. Water holding capacity increases significantly under DT. There was a significant interaction effect of tillage and irrigation treatments on WHC. On the contrary, bulk density decreases significantly under DT and CT. The zero tillage gave lower values of total porosity in both soil layers. Soil penetration resistance was significantly lower under tillage (deep, conventional) and irrigation treatments. Plant height, number of spikes/m2, number of grains/spikes, 1000- grain weight, flag leaf area, grain yield, and biological yield were all highest in wheat plants that were irrigated four times (IR3). Water usage efficiency declined as the number of irrigations increased, with wheat plants watered twice (IR1) having the best water use efficiency. Deep tillage had significantly positive effect on increasing the grain yield and its components compared to conventional tillage and zero tillage. Wheat plants under deep tillage showed the highest consumption of quantity of irrigation water, total used water. The highest consumption of irrigation water under deep tillage associated with the highest water use efficiency.