To investigate the effect of different intervals of water stress and cycocel (CCC) levels on yield and yield components of some rice cultivars (Giza179 and Sakha108), at the farm of Agricultural Research Station, Sakha, Kafrelsheikh, Egypt, during 2018 and 2019 successive rice seasons, a strip-split plot design with four replicates was used. The treatments included three irrigation intervals (I₁:4, I₂:8, and I₃:12 days intervals and four foliar application levels of cycocel hormone (T₁:control; T₂:250; T₃:500; and T₄:750 ppm) on two rice cultivars (Giza179 and Sakha108). It was observed that during the foliar application of chlormequat chloride cycocel (CCC), leaf area index (LAI) and dry matter significantly increased by increasing cycocel levels up to 500 ppm while application of cycocel up to (C4) led to increasing chlorophyll content. Number of panicles m^-2, number of filled grain panicle^-1, 1000-grain weight and grain yield significantly increased up to 500 ppm as compared to control and 750 ppm (C4) treatments. At all different water intervals and cycocel interaction, data show that foliar application of cycocel up to 500 ppm may improve growth and yield characters under different irrigation intervals up to irrigation every 12-days. While there was no significant difference between rice cultivars under this study on grain yield, on the other hand, Giza 179 mark superiority at all growth and yield characters than Sakha108 which recorded positive results with cycocel as foliar application. It was concluded that cycocel maybe a good tool for improving rice yield under drought stress.