Detection of cowpea rust disease was carried out in 13 distracts of Dakahlia governorate. The high disease incidence was in Sherbin distract followed by Tmai Elamdid distract. While, the low disease incidence was in Aga distract. On the other side, the high value of disease severity occurred under Tmai Elamdid, Mit Salsyl and Bilqas distracts. While, Minit Elnasr distract was came late. Foliar application of microelements at all tested concentrations and also fungicide (Plantvax 20% EC 1m/l) significantly decreased the infection with Uromyces vignae. The best results were obtained from boron at 0.05 g/l followed by manganese 3 g/l then ferrous 3 g/l. All tested microelements caused significant increase in plant height and number of branches, leaves and pods/plant. The low concentration was more effective than the higher one except ferrous which gave the reverse. While there was no significant effect due to fungicide treatment on these parameters. The highest values of 100-seeds weight occurred under boron application at 0.05 g/l followed by manganese at 3 g/l then boron 0.025 g/l. The high total phenol content in cowpea leaves were obtained from the application of boron at 0.05 g/l followed by manganese at 3 g/l then manganese 2 g/l. In all tested microelements treatment a significant increase in chlorophyll a, b and caroteinoids content was achieved compared with fungicide and check treatments. This study indicates that, there is a correlation between induced resistance for rust disease and accumulation of phenols.