Five bread wheat varieties were sprayedwith the recommended doses to investigate the effect of three systemic fungicides belonging to triazole group i.e. (Punch), ( Sumi-8 ) and ( Fungshow) on leaf rust severity, meiotic aberration,chlorophyll content and yield components ,.All the used fungicides enhanced the yield components of the wheat varietiesand reduced the severity of disease leaf rust disease as compared with the control treatments. The wheat variety Gemmeiza-10 showed the lowest disease severity followed by Sakha-61 , Sids-1 , Gemmeiza-7 then Sakha-93 as a result to use the tested fungicides. Significant differences were found either between the fungicides or between the wheat varieties concerning yield components, chromosome aberration and micronuclei, and pollen viability .The three fungicides showed chromotoxic effects on meiotic cells ,which reduced the meiotic activity and resulted in accumulation of metaphase cells and increased the chromosomes aberrations in the wheat varieties.  Punch( Flusilazole) followed by Sumi-8( Diniconazole) were the most effective , while Fungshow(Diniconazole) was the least one in this respect. Also, fungshow and sumi-8 showed the highest percentage of pollen viability (97.77and 97.43), while Punch slightly reduced the percentage of pollen viability (96.82) comparing with the control treatment ( 98.43). In general, it could be concluded that although systemic fungicides can be used at the recommended rate for the control of plant diseases and enhance plant growth and yield quantity in breeding programs. care should be taken while using these systemic fungicides and should be exploited judiciously .