The present study was carried out at  two Experimental Farm ,Al-Azhar  Univ. at Assiut and Shandaweel Research Station at Sohag  .The performance and  heterosis in grain sorghum with reduced water applied used were studied .Five female sterile lines (A-lines) with six Egyptian restorer lines( R-lines ) released from Egyptian program  at Shandaweel. The parents were crossed to produce  thirty crosses .Forty two  genotypes (30 hybrids  and their 11 parents as well as  the hybrid Shandaweel 6 as check were evaluated in summer growing season 2004 in two locations Assiut and Sohag.  The combined analysis of variance over locations, showed  highly significant differences among parents and crosses. Interaction  effects were  significant for parents  and crosses with locations for all studied traits.  Results indicated that two B-lines (BTX-89002 and ICSB-35) and two R-lines (Adv.3/2002 and Adv.4/2002) were drought tolerance genotypes and gave the highest DTI(drought  tolerance  index) and lowest DSI(drought  susceptibility  index).  The estimates of  heterosis for grain yield/ plant indicated that ,the crosses (ICSA-70x RTX-2794 ),( ICSA-70x RTX-2895)  and (ICSA-155x  RTX-2895) had the best heterotic effect over the two locations under both irrigation levels. Also ,these crosses are drought tolerance and significantly outyielded the check Shandaweel -6.