Surveying the plantation areas of blond psyllium (plantago ovata), as a new remunerative medicinal crop grown during 2005/2006 and 2006/2007 winter seasons, showed that the wilt and root rot diseases were recorded for the first time in Egypt. In the experimental area at Agronomy farm, plants showed symptoms of yellowing stunting and dried shoots, as well as xylem discoloration and a cortical root rot were noticed. Isolation trials yielded Fusarium incarnatum, F. oxysporum, F. solani, Rhizoctonia solani and Sclerotinia sclerotiorum. Pathogenicity tests indicated that all isolates were equal in their significant effects in pre-emergence damping off symptoms. Where, F. incarnatum, F. oxysporum and F. solani were the most virulent in post-emergence damping off, while R. solani and S. sclerotiorum were the last ones. From Trichoderma viride, T. harzianum, T. hamatum, Gliocladium virens, and G. rosum, T. viride and T. harzianum antagonized F. incarnatum and showed the maximum significant inhibition effect. The radial growth of F. solani was highly affected by T. harzianum and G. virens. Besides, G. virens exhibited the highest reduction of Rhizoctonia solani growth. The antagonistic behavior of Trichoderma and Gliocladium species resulted from growth of antagonistic fungi over all psyllium pathogens. In pot experiment, the combined soil infestation with G. virens and F. solani recovered the highest percent of survival plants (75%) and maximized the plant height, number of leaves, spikes, fresh and dry weights plant^-1. In general, the presence of antagonistic fungi reduces the deleterious effect of wilt causative pathogens on growth parameters of psyllium plants.