Increased range of virulence of stripe rust caused by Puccinia striiformis Westend f. sp. tritici Eriks. & E. Henn. on wheat (Triticum aestivum, L.) of Egyptian commercial wheat cultivars has required assemblage of a broad genetic basis of resistance. Plant reactions of some wheat Egyptian cultivars were evaluated in 16 crosses included parents, F₁'s and F₂'s plant population from resistant by susceptible and susceptible by susceptible parents crosses suggested that digenic control plant reaction to the fungus. Of course, digenic expression is more common in field; also, no segregation was recorded neither with susceptible/susceptible cross nor the resulting susceptibility. Some cultivars exhibited resistance i.e., Giza 168, Sids1 and Giza 144 which were crossed with other susceptible wheat cultivars i.e.,  Gemmeiza 1, Giza 162, Giza 163, Sakha 8 and Sakha 69 probably had combined gene(s) that work against fungus. Some cultivars had different gene(s) for the adult plants. The F₂ progeny that was derived from susceptible parents expressed digenic control of resistance or susceptibility. Genetic diversity was modest among the various cultivars except for susceptible / susceptible cultivar cross expressed epistasis of progeny than parents.