Two field experiments were conducted at private farms in El-Semblawin, Dakahlia  Governorate during 2005 and 2006 seasons to investigate the effect of cultivars (Giza 111, Crawford, Giza 35 and Giza 21) and fertilization treatments (farmyard, chicken, urea, 75% farmyard + 25% urea and 75% chicken + 25% urea) on growth, yield and yield components as well as seed oil and protein contents. A spilt plot design with four replications was used. The obtained results can be summarized as follows: 1-   Plants of Crawford were taller than the other cultivars (Giza 21, Giza 35 and Giza 111) in both seasons. While Giza 21 gave the highest number of branches, number of flowering groups and number of  pods per plant, number of seeds/pod, number of seeds/plant, seed weight/plant, 100-seed weight, seed yield (ton fed) and oil and protein contents. While, Crowford gave the highest straw yield (ton/fed). However, Giza 111 gave the highest stem diameter as compared to the other cultivars. 2-   Application of 75% chicken + 25% urea significantly increased all the studied characters of soybean cultivars in both seasons. 3-   The interaction between Crawford and 75% chicken + 25% urea in both seasons had a significant effect on plant height and straw yields (ton/fed). 4-   The interaction between Giza 21 and fertilization with 75% chicken + 25% urea gave the highest number of branches and oil content in the first season only. 5-   The interaction between Giza 21 and fertilization with 75% chicken + 25% urea gave the highest values of number of flowering groups per plant, number of branches per plant, number of pods/plant, seeds weight/plant, 100-seed weight and seed yield (ton/fed) as well as oil and protein % of soybean seeds.