Two field experiments were conducted during winter seasons of 2019/2020 and 2020/2021 in the Experimental Farm, Faculty of Agriculture and Nature Resources, Aswan University, Aswan, Egypt. The main objective behind this study is to investigate the effectiveness of potassium fertilization and proline exogenous application on potato growth, yield and quality at arid regions. Nine treatments were as follows: control, soil application with potassium at 50 and 100 kg K₂O/feddan singly or in combined with three proline levels (50, 100 and 200 mg/l). The experimental layout was Randomized Complete Blocks Design with three replications. Generally, the obtained results indicated that soil application with 100 kg K₂O/feddan (200 kg potassium sulfate) with proline foliar application at 200 mg/l recorded the highest average values of vegetative growth, yield and chemical composition of leaves and tubers and might be considered as an optimal treatment to produce high yield and good quality of potato plants under the environmental conditions of Aswan governorate and other similar regions.