Globe artichoke is one of the most important vegetable crops in the countries bordering the Mediterranean basin including Egypt. Globe artichoke cv. 'Balady' is the most preferred by Egyptian farmers, but due to lateness of its flowering, lowering its yield capacity it is facing extinction among the Egyptians. Therefore, two field experiments were carried out during the seasons of 2019/2020 and 2020/2021 as an attempt to improve its yield and quality. The experiments were executed in a private farm located at Abou El-Matameer city, in Behiera Governorate, Egypt. Three chitosan concentration were used, included control, 150 and 300 mg/l.Also, four concentrations of salicylic acid were used in the present study (0, 50, 75 and 100 mg/l) as a foliar spraying individual or in combination. The spraying was applied twice; the first one was carried out after 65 days from planting, the second application was 20 days after the first one. The untreated plants were sprayed with tap water. The layout experimental was factorial experiments in a Randomized Complete Blocks Design with three replications.The obtained results indicated, generally, that the higher concentration of chitosan (300 mg/l) and salicylic acid (75 mg/l) separately or in mixture recorded the highest average values and might be considered as an optimal treatment for the production of high yield and good quality of 'Balady' cv. globe artichoke plants under the environmental conditions of Behiera Governorate and other similar regions.