A greenhouse experiment was conducted during the summer seasons 2019 and 2020 to evaluate the effect of sunflower grains priming in different concentrations of salicylic, ascorbic acids, hydrogen peroxide, thiamine, nitric oxide and Oxamyl growth parameters of sunflower plants under the stress of nematode infection. The best effect was reach by the seed soaking of Nitric oxide at 100 ppm(stem height 66.4 cm; root length 81.96 cm;shoot fresh weight 414.2 g;root fresh weight 201.86 g; shoot dry weight 65.76 g).Meanwhile,the less efficiency was reach with the seed soaking of hydrogen peroxide at 50 ppm (stem height 47.66 cm; root length 53.36 cm; shoot fresh weight 263.6 g; root fresh weight 126.28 g; shoot dry weight 49.52 g). Nematicide Oxamyl (stem height 34.3 cm; root length 32.94 cm;shoot fresh weight 156.0 g; root fresh weight 72.3 g; shoot dry weight 37.94 g) followed by control non soaked the best effect was reached over both season by the seed soaking of hydrogen peroxide at 100 ppm (N: 7.32%; P: 0.78%; K: 6.5%; phenol: 117.1; POX: 1.4; Chlorophyll a: 1.1; Chlorophyll b: 0.7; Total Chlorophyll: 1.74; and Carotene: 1.28). Seed priming in nitric oxide (100 ppm), chitosan(50 ppm)and chitosan(100 ppm), consequently produced the highest averages of seedling growth parameters as compared with the other treatments over both seasons. On the other hand, seed priming in H₂O₂ at 100 ppm, thiamine at 50 ppm, thiamine at 100 ppm and nitric oxide at 50 ppm resulted the highest values of chemical parameters over both seasons.