During summer seasons of 2015 and 2017, a field experiment was conducted at the Research and Experimental Station (30°19′ N, 31°16′ E), Faculty of Agriculture, Ain Shams University at Shalakan, Kalubia Governorate, Egypt, to investigate the effects of combinations between hydroxyl apatite nanoparticles (0, 3, and 6 kg/fad) and calcium carbonate nanoparticles (0, 500g/fad) as nano-fertilizers under irrigation intervals, (irrigation every 2 or 3 weeks whereas irrigation every 2 weeks as a recommended practice) on yield components and quality of soybean plants. Plants irrigated every two weeks produced higher seed and biological yield in the two resulted seasons; and its combined. Interaction between 6 kg/fad hydroxyl apatite nanoparticles (A₃)and 500 g/fad calcium carbonate nanoparticles (C₂) under irrigation every 2 week (IR ₁) recorded the maximum values of 100-seed weight, pod yield, seed and biological yield . On the other hand the lowest means values were recorded at combination between zero kg/fed hydroxyl apatite nanoparticles (A₁)and zero g/fed calcium carbonate nanoparticles (C₁) under irrigation every 3 week (IR ₂). Regarding to chemical composition interactions of irrigation intervals x apatite concentrations x nano calcium carbonate scored the highest and significant oil% and protein %.  Interaction between 6 kg/fed hydroxyl apatite nanoparticles (A₃)and 500 g/fed calcium carbonate nanoparticles (C₂) under irrigation every 2 week (IR ₁) recorded the maximum values of yield and quality studied traits of soybean plants.