This work was conducted during the 2019 and 2020 seasons at the Agricultural Research Station in Sakha, Egypt to study the effect of various biofertilizers (Rhizobacterin and non-fertilized) and weed control treatments (pendimethalin 1.7 L/acre, Prometric n 1.25 L/acre, Pendimethalin). 1.7 L/acre + Fluazifob-p-butyl 1.5 L/acre, Prometrine 1.25 L/acre + Fluazifob-p-butyl 1.5 L/acre, scrabble 15 days after sowing (DAS) + Fluazifob-p-butyl 1.5 L/acre wice manual hoeing and control (untreated assay) on soybean nodules, weeds and yield. The results indicated that biofertilization (Rhizobacterin) and weed control treatments increased the nodule number, weight, plant height, number of branches, number and weight of pods, seed yield and seed yield/acre. of soybeans in the two years compared with un-Rhizobacterin plants. Moreover, the content of protein, oil, nitrogen and protein in soybean seeds increased in the two seasons. From the results obtained, bendemethalin 1.7 L/acre + fluazifob-p-butyl 1.5 L/acre, manual hoeing twice at 21, 35 days post-seeding (DAS) and cribbing 15 days after sowing + fluazifob-p-butyl 1.5 L / Feeding was the best treatment which gave the best weed control. Therefore, it is recommended to search using the Rhizobacterin in vivo fertilization, soybean plants were treated with pendimethalin 1.7 L/acre + fluazifop-p-butyl 1.5 L/acre, manual hoeing twice at 21, 35 days after sowing (DAS) and scribbling 15 days after Sowing + fluazifob-p-butyl 1.5 L/acre gave the highest soybean seed yield and the best weeding control under experimental conditions