Three times of application were randomly distributed in main plots; however, five herbicidal mixtures and control treatments were allocated in sub-plots. Lolium, Phalaris as narrow leaf and Medicago hispida as broad leaf weeds were dominant in first, second and both seasons, respectively. All studied mixtures under three application timing caused 100% control of broad leaf weeds. Most of herbicide mixtures, especially with Co-formulated at higher dose (0.12 kg/ha) provided suitable control level for Phalaris and Lolium at first and second application timing compared with third one. So, the optimum time to apply post-emergence herbicide mixtures is at tillering stage "B" of wheat. All herbicide mixtures recorded low indexes of injuries on wheat plants which disappeared completely after 4 weeks from herbicide application, except with third application timing in the first season which gave some phytotoxicity up to 6 weeks because of rain full after two hours from herbicide application. Application herbicide mixtures, generally increased wheat plant growth, grain yield, number of effective tillers/m², number of grains /spike¹,100-grain weight, and harvest index in the two seasons, compared with unweeded treatment. Foliar application of the studied herbicides at tillering stage "B" of wheat crop produced the highest growth, grain yield, attributes, grain protein and gluten contents, followed by early application at two leaves "A" growth stage. The best results for wheat growth, yield and grain quality traits resulted from Co-formulated herbicide mixtures application at wheat tillering growth stage.