Wheat cv. Sakh 93 was planted on a clay soil at Agricultural Research Station Farm, Kafrelsheikh, in 2014/2015 and 2015/2016 seasons to investigate the influence of irrigation regime (irrigation at 40, 55, and 70% depletion of available soil moisture, DASM), nitrogen rates (50,70 and 90 kg N/fed.) and potassium rates (0,12 and 24 kg K₂O/fed.) on productivity and certain water relations. The reduction in DASM from 70% to 40% at irrigation and increasing either nitrogen or potassium rates resulted in significant increases in spike number m^-2, grain number/ spike, 1000-grain weight,  grain yield, water Applied (WA), water Consumptive Use (WCU), productivity of Water Applied (PWA), productivity of Water Consumptive Use (PWCU), stored Water (SW). Irrigation at 55% DASM with 70 kg N and 24 kg K₂O/fed^-1 recorded the best values of PWA for grain (1.12 and 1.09 kg grain m³ AW). Raising the nitrogen rate from 50 to 90 kg N fed^-1 significantly raised water applied efficiency (WAE %) in both seasons. Irrigation  at 70% DASM with 90 kg N and 0 kg K₂O fed^-1 produced the highest values of WAE (86.43 and 86.98 %), while irrigation  at 40% DASM with 50 kg N and 24 kg K₂O/fed produced the lowest values (71.77 and 71.60 %) in both seasons.  In conclusion, irrigation at 55% DASM with application of 70 kg N and 12 or 24 kg K₂O fed^-1 was the best treatment, which resulted in high grain yield with fewer amounts of applied irrigation water and consumptive use.