The present investigation was carried out in a private farm located at Alexandria Desert Road (km 64), Giza Governorate, Egypt to calculating heat requirements and generation flowering of some pomegranate cultivars (H 116, Wonderful and Manfalouty) grown in Giza Governorate during 2018 and 2019 seasons.Results showed that under Giza Governorate conditions, average of effective heat summation requirement from red tip to harvest stage for H 116, Wonderful and Manfalouty are (1789, 2403), (2982, 3569) and (3036, 3602) growing degree days (GDD) during the two season of the study, respectively. Also, found that the first generation of flowering gave the highest value of fruit length and diameter (cm), fruit weight (g) and acidity (%).While, the second generation of flowering gave the highest value of fruit weight (g), number of fruit/tree, yield (kg/tree) and total soluble solids (%).Generally, it can be concluded that the effective heat summation requirement of Giza Governorate is suitable for commercial growing for (H 116, Wonderful and Manfalouty) cultivars. The first generation of flowering is good for production big fruit, while the second generation of flowering is suitable for production quantity and quality of fruits pomegranate.