Two open field experiments were conducted during summer seasons of 2019 and 2020, in a private farm at Abou El-Matamer district, Behiera Governorate, Egypt. Certified imported potato seeds of 'Cara' cv. were used after splitting-up. Cut seedy explants (ca. 40 g) contain two eyes each were planted at 0.80 m wide and 0.20 m apart between hills, using four concentrations of synthetic NAA auxin (control, 25, 50, and 100 mg l^-1)  and four concentrations of the synthetic cytokinin BA (control, 25, 50, and 100 mg l^-1) were foliar applied separately and in combinations. Control plants were sprayed with distilled water. The effects of both variables and their combinations were investigated on the vegetative growth-related characters, yield and its components, leaves and tubers chemical composition. The obtained results declare, in general, that foliar application treatments of auxin (NAA) and cytokinin as BA alone or in combination to potato plants gave, significantly, the highest average values of both yield and chemical content compare to untreated plants. The combination between 100 mg l^-1 NAA plus 100 mg l^-1 BA might be considered as an optimal treatment for the production of high yield and good quality of potato plants under the environmental conditions of Behiera Governorate and other similar regions.