Two successive growth seasons were conducted at Two locations in 2005/2006 and 2006/2007 growing seasons.1-Wadi Sudr Agricultural Experimental Station, Desert Research Center South Sinai Governorate (saline soil). 2-Maryut Agricultural Research Station, DesertResearchCenter, at Maryut region, 35 Kms. west Alexandria (sandy and calcareous soil). This study was conducted to evaluate the effect of three weed control treatment and three foliar application as well as three biofertilizer treatments on acclamation and improving growth, yield and its components as well as the Chemical composition of barley plant grown under saline and calcareous soil conditions . Split split plot design with three replications was used, the main plots were devoted at random to the weed control, i.e., Topik140 g/fed , Derby 30Cm/fed and tap water as a control and three foliar application treatments, i.e., Kcl 2% , Biomagic 3Kg/fed and tap water as a control in the sup plot as well as three  biofertilizer treatments, i.e., Nitroben 1Kg/fed and Seryalen 800g/fed and tap water as a control in the sub sub plots . The obtained results could be summarized as follows: Topik as a weed control treatment was better than Derby for all growth traits, yield and yield components as well as chemical composition of barley plant under saline and calcareous soil in 2005/2006 and 2006/ 2007 growing seasons. However, Kcl 2% as a foliar application recorded the highest significant mean values for all growth traits, yield and yield components as well as chemical composition of barley under saline soil during both seasons. Biomagic 3Kg/fed. Surpassed the other foliar application for increasing growth traits, yield and its components as well as accumulation of carbohydrates, protein and prolein contents in barley plants under calcareous soil during both seasons. Generally, inoculation of seeds by Seryalen biofertilizer treatment was better than Nitroben for growth traits yield and its components in addition, chemical composition of barley plant as compared with the control under saline and calcareous soils condition.