A split-plot field experiment with three replications was performed at the experimental Farm of Etay El- Baroud Agricultural Research Station, El- Behera Governorate during 2018/2019–2019/2020 seasons to determine optimum irrigation treatments for achieving the highest grain yield of some bread wheat genotypes and determining selection criteria for improving grain yield per plant. The three irrigation treatments i.e. I₁= Irrigation at tillering + elongation stage, I₂ = Irrigation at tillering + elongation + booting stage, I₃ = Irrigation at tillering+ elongation + booting + heading occupied the main plots and six wheat genotypes i.e.; Misr 2, Gemmeiza 11, Misr 1, Shandweel 1, Line 1 and Line 2 were in sub plots. Sowing of cultivar Misr 1 under the second irrigation treatment gave the highest number of spikes/m² (454.33 spike), number of kernels/spike (56.17 kernel), grain yield (25.48 ardab/fed), and harvest index (38.89%), hence it was the best recommendation for wheat growers. Water Use Efficiency (WUE) was recorded the highest values (1.23) at I₁ for Misr 1, which produced the highest grain yield and water use efficiency. Number of kernels/spike (0.61) followed by spike length (0.1846)had the largest direct effect on grain yield, hence, hence they are considered as the best selection traits for improving grain yield as reveled by path analysis. Moreover, multivariate analysis indicated that number of kernels/spike, number of spikes/m², spike length and 1000-kernel weight could be the reliable criteria for selecting better genotypes in second irrigation treatment (I₂).