The field experiments were carried out in Sakha Agric. Res. Station at Kafr El-Sheikh Governorate, Egypt, during 2018 and 2019 seasons to study the effect of Nano-fertilizers and its concentrations on growth, yield and its components and fiber quality to increasing productivity of cotton to Giza 96 variety. The design of experiment was a split- plot with 4 replications. The main plots included the Nano. Compounds (Nano- Silica, Nano- Iron, Nano-Copper and Nano- Zinc) and the sub plots involved three concentrations (250, 500 and 1000 ppm ). Foliar spraying three times (at squaring, initiation of flowering and 2 weeks after flowering). The obtained results were as follows: Nano-fertilizers and fertilizer concentrations and their interaction had significant effect on plant height, No. of fruiting branches /p, first fruiting node, No. of open bolls/plant, boll weight, seed index, and seed cotton yield/fed. but gave insignificant effect on lint percentage,  fiber parameters (fiber  length, uniformity %, strength and micronaire reading). Spring Nano-Si significantly increased plant height, No. of fruiting branches /p., seed index and seed cotton yield/fed. and its components ( No. of bolls/plant and boll weight) as compared with the other Nano- fertilizers (Fe, Cu and Zn). The high concentration of Nano-fertilizers 1000 ppm gave the good values of growth and yield and yield components. Spring Nano-Si with 1000 ppm fertilizer concentration gave the good values of growth and yield. It could be concluded that sparing Nano Si with high concentration 1000 ppm three times gave high productivity of Giza 96 cotton variety under the conditions of Kafr El-Sheikh Governorate.