Two field experiments were conducted during the seasons of 2017-2018 and 2018-2019 at Baramoon Research Station, Mansoura, Dakahlia Governorate, Egypt, to study the effect of irrigation intervals and foliar application with nano-potassium and boron fertilizers under mineral potassium fertilization on productivity and quality of globe artichoke French Hyrious variety. The experiment divided into 36 treatments, representing the combinations of three irrigation intervals (10, 20 and 30 days) as vertical-plot, three rates of potassium fertilization (50, 75 and 100%) as horizontal plot and four foliar application rates of Nano-fertilizers (without, 3000 ppm K, 50 ppm B and 3000 ppm nano-K + 50 ppm nano-B) as split plot. The design of the experiment was a strip-split plot with three replicates.  The results indicated that the fertilization of globe artichoke plants with potassium at 100% (200 kg/fed. potassium sulfate.) or 75% (150 kg/fed. potassium sulfate.) with foliar application by a mixture of 3000 ppm nano-K+ 50 ppm nano-B treatment and irrigation every 20 days to obtain the best yield (early and total) parameters and the highest quality. Therefore, we recommend this treatment because it saves in the amount of potassium and the amount of irrigation water and thus reduces the costs of artichokes production and environmental pollution under the conditions of this study.