Two field experiments were conducted  at Baramoon Research Station, Mansoura, Dakahlia Governorate, Egypt, during the two seasons of 2017-2018 and 2018-2019, to investigate the effect of irrigation intervals and foliar application with nano potassium and boron fertilizers under mineral potassium fertilization on plant vegetative growth parameters and mineral content in leaves of globe artichoke, French Hyrious variety. The experiment included 36 treatments, representing the combinations of three irrigation intervals (10, 20 and 30 days) as vertical-plot, three rates of potassium fertilization (50, 75 and 100%) as horizontal plot and four foliar application rates of Nano-fertilizers (without, 3000 ppm K, 50 ppm B and 3000 ppm K + 50 ppm B) as split plot. The design of the experiment was a strip-split plot with three replicates. The results revealed that the fertilization of globe artichoke plants with potassium at 100% (200 kg/fed. potassium sulfate.) or 75% (150 kg/fed. potassium sulfate) with foliar application by a mixture of 3000 ppm nano-K+ 50 ppm nano-B treatment and irrigation every 20 days to obtain the best vegetative growth parameters and the highest nutrient contents.