Two field experiments were conducted at Agricultural Research and Experimental Station, Faculty of Agriculture, Cairo University, Giza, Egypt during  2017 and 2018 seasons to evaluate the response of two Egyptian cotton cultivars to the balanced between macro and micro fertilization as foliar application. The experiment included 14 treatments which were the combination of two cultivar and the foliar application of  six chemical nutrient solutions (zinc 100 mg/L, zinc 200 mg/L, boron 500 mg/L, boron 1000 mg/L, novatreen 1L/fed and citreen 1 L/fed) in addition to control treatment. The experiment was laid out in a randomized complete block design with split plot arrangement with three replications. The cultivars were allocated in the main plots and the foliar application of  nutrient were distributed in sub-plots. The two cultivars significantly varied in almost of studied traits. Giza 196 cultivar significantly exceeded Giza 195 in plant height, number of sympodial branches/plant, total number of bolls/plant, boll weight, seed index, lint%, seed cotton yield. Also, Giza 196 significantly surpassed Giza 195 in fiber length, fiber strength, fiber elongation and micronaire. Compared with control,  the foliar of nutrient solutions significantly increased growth characters, seed cotton yield and yield components. Furthermore, spraying of nutrient solutions significantly improved fiber technology characters, macro and micronutrients contents of cotton leaves, biochemical compositions of leaves and  both oil and protein contents of cotton seed in both seasons. Generally, novatreen recorded the best for all studied characters. The interaction between cotton cultivars and nutrient solutions was significant regarding most of studied traits.