Two field experiments were conducted during 2004/05 and 2005/06 seasons at Shandaweel agriculture research station, Sohag governorate, Egypt to study the effect of four sowing methods (broadcasting, afir drilling, Herati and Afir in ridges) and three weed control treatments (Brominal & Topik herbicide, hand weeding and unweeeded control) on growth, yield and yield components of wheat cultivar Giza 168. Split plot design with three replications was used. The results indicated that sowing methods had no significant affects on dry weight of annual weeds in both seasons except narrow and total weeds in second season.Herati and Afir drill methods reduced dry weight of narrow and total weeds by 27.6, 24.9, 25.8 and 20.0 %, respectively in second season, as compared toAfir broadcast method. Weed control treatments had significant affect on dry weight of annual weeds in both seasons, as compared to weedy check. Hand weeding twice andBrominal + Topik reduced dry weight of annual broad, narrow and total weeds by (92.9 &94.8), (91.4 & 93.1) and (93.0 & 91.9%), respectively in the first season and by (99.3 &97.4), (98.8 & 99.2) and (98.9 & 98.7%),, respectively in second season, compared to untreated treatment. Sowing methods had no significant influence onyield and its componentinboth seasons exceptplant height, spike length and straw yield (ton/fed.) in second season and number of spikes/m2 and grain yield (ard./fed) in both seasons. For grain yield (ard./fed), the highest values were obtained from Herati method by 11.3 and 14.2 ard./fed compared with Afir broadcast and Afir in ridges methods by 6.8 and 7.0 ard./fed, respectively, in both seasons. All weed control treatments exerted a significant influence on yield and its componentinboth seasons except spike length and grain weight/ spike in second season. The highest values of wheat grain yield (ard/fed) was from application hand weeding twice and Brominal plus Topik by 11.4, 10.3, 12.1 and 11.7 ard./fed. compared with weedy check (6.5 and 7.7 ard/fed), respectively, in both seasons. All interactionsbetween sowing methods and weed control treatments had no significant effects on all studied charactersinboth seasons except dry weight of narrow and total weeds (g/m2) in second season, number of spikes/m2 in both seasons and wheat grain yield (ard/fed) in first season. From this investigation can concluded that using herati or afir drill sowing methods with hand weeding or brominal +Topik gave the highest reduction of weeds and increase wheat grain yield.