Field experiment was carried out through 2018 season and repeated through 2019 season at El-Gemmeiza Agricultural Research Station, El-Gharbia Governorate, Egypt. These experiments aimed to study the effect of three foliar sprays with chelated magnesium and/or zinc on productivity and quality of the Egyptian cotton cultivar Giza 86. Two levels (2 and 4 g of each nutrient/liter water (,in addition to the control treatment were used. The experimental design was a randomized complete blocks with 3 replications.The data indicated that combination between chelated magnesium and chelated zinc at the two levels used significantly increased the concentrations of Mg, Zn and photosynthetic pigments in the leaves in both seasons. In addition, combination between chelated magnesium and chelated zinc at the low level (2 g/liter water of each nutrient) significantly increased total dry weight/plant, leaf area index, plant height, number of fruiting branches/plant, number of total flowers/plant, number of total bolls set/plant, boll setting percentage, earliness percentage, number of open bolls/plant, boll weight, seed index, lint percentage and seed cotton yield/feddan, fiber length, uniformity index and fiber strength in both seasons. The control treatment recorded the lowest values of these traits and significantly increased boll shedding percentage. Micronaire reading was insignificantly affected. It could be concluded this combination three times to obtain the high quality and productivity and recommended the possibility of being applied by farmers to enhance cotton productivity in light of the lack of magnesium and zinc in the soil under conditions similar to El-Gemmeiza region.