Two field experiments were carried out at Tag-El- Ezz Research Station in Dakahlia Governorate, Agric–Res-Center, Ministry of Agric. during 2007 and 2008 seasons to investigate the role of selected antioxidants on mitigate or alleviate the harmful effect of drought stress condition on biochemical constituents of maize  plant. Iirrigation intervals (14, 16, 18 and 20 days) decreased photosynthetic chlorophyll a, b, carotenoids in the leaves of  maize  plants during the two growing seasons,  irrigation every 20 days was the most effective treatment in decreasing photosynthetic pigments.  Concerning the applied antioxidants, it could be showed that each of the applied antioxidants (Citric, ASA or SWE ) increased photosynthetic pigments content in the leaves of  both maize  during the growing seasons. Moreover, SWE treatment was the most effective in this respect. AS for the interaction effect, it could be show that all applied antioxidants enhanced the contents of photosynthetic pigments  under drought stress levels (irrigation  every  16, 18, 20 days ) . This is clear when compared with drought stress treatments only but these values were stell under or nearly to control treatment. As for Endogenous  and non-enzymatic antioxidants it could be showed that irrigation intervals treatments and applied antioxidants such as total phenol, proline, ascorbic and glutathione as well as their interactions slightly increased all endogenous  enzymatic antioxidants contents as well as SOD, APX and Catalase activities in the shoot of maize plants during the two growing seasons. SWE and  irrigation every 20 days were most effective in this respect.    As for N,P ,K contents ,it could be show that drought stress treatments  decreased N, P and K contents in leaves and stems of   maize plants during the two growing seasons  ). Moreover high drought stress level ( irrigation  every  20 days ) was the most effective in decreasing N, P, K contents . Contrarily, the data show that applied antioxidants slightly increased N, P , K contents in the different organs of  maize  plants during the growing seasons. Concerning interaction treatments, it could be show that applied antioxidants enhanced the contents of N, P , K in leaves and stems of   maize  plants under drought stress treatments (irrigation  every  16, 18, 20 days ) compared to the drought stress treatments only. But these increases were less or nearly to the control treatment.