Two field experiments were carried out during winter seasons 2004/2005 and 2005/2006 in Experimental Station of National Research Centre, Shalakan District , Kalubia Governorate , Egypt . The aim of the study was to examine the response of wheat cultivar Sakha-93 to 3 weed control treatments and two sowing methods.The experiment included 6 treatments which were the combinations of two sowing methods 1- in ridges 2- rows and response of wheat cultivar Sakha-93 to 3 weed control treatments 1-Unweeded (control) ; 2-Hand weeding twice at 30 and 60 DAS 3-Chemical weed control by Panther 55% Sc at post emergence . The treatments were arranged in split plot design in four replicates, sowing methods in main plots and weed control treatments in subplots. Combined analysis used for the two seasons. Data indicated that sowing wheat c.v Sakha-93 in ridges surpassed in rows for no. of tillers ; spikes/m² ; spike length ; spike weight ; grains weight/spike ; grain; straw; biological yields as kg/fed.; harvest index % ; protein ; phosphorus and K yields as kg/fed. On the other hand, sowing in rows produced taller plants, heavier 1000 grains weight . . Results showed that chemical weeded had superiority in total, broad leaved ,grassy weeds either fresh or dry/m² at both samples 75 and 105 DAS ,also, in no. of tillers/m² ; no. of spikes/m² ; spike length ; spike weight ; grains weight/spike ; 1000-grains weight ;  grain yield/fed. ; harvest index% ; protein ,P,K yields (kg/fed.) whereas hand weeding produced tallest plants , highest protein ,P,K% in grains. Interaction of sowing method in ridges and chemical weeded significantly surpassed other treatments in no. of tillers/m²; no. of spikes/m² ; spike weight ; straw and biological yield as kg/fed. Interaction of sowing method in ridges and hand weeding gave the highest content of protein ; phosphorus and potassium in wheat grains as kg/fed.