This study was conducted at a Privet Nursery in New Damietta City, Damietta Governorate, Egypt during the two consecutive seasons of 2017/2018 and 2018/2019 in split-plot design in three replicates to estimate the effect of salinity levels (control (tap water), 3600, 5400 and 7200 ppm) as main plot and foliar spraying with (distilled water, salicylic acid, proline, yeast extract and licorice roots extract) as sub plot as well as their combination treatments on chemical constituents of neem plants (Azadirachta indica). The obtained results revealed that with increasing salinity levels photosynthetic pigments, reducing and non-reducing sugars as well as mineral contents (N, P, K, Ca and Mg) of neem leaf were decreased but it not suffered to level 3600 ppm and recorded the highest values, while content of proline, total phenol and Na increased with increasing salinity levels to 7200 ppm. As for the effect of foliar application found that plant sprayed with proline followed by licorice extract resistance the salinity and recorded the highest values of all mentioned traits. Interaction treatments between foliar application and salinity treatments recorded highest values for all traits with proline under 3600 ppm except Na, proline and total phenol at 7200 ppm under foliar spray with proline at 0.2 g/l.